منابع مشابه
Protein structure evolution and the SCOP database.
The structure of a protein can elucidate its function and its evolutionary history (seeChapters 18, 21 and 23). Extracting this information requires knowledge of the structure and its relationships with other proteins. These in turn require a general knowledge of the folds that proteins adopt and detailed information about the structure of many proteins. Nearly all proteins have structural simi...
متن کاملS4: structure-based sequence alignments of SCOP superfamilies
S4 is an automatically generated database of multiple structure-based sequence alignments of protein superfamilies in the SCOP database. All structural domains that do not share more than 40% sequence identity as defined by the ASTRAL compendium of protein structures are included. The alignments are constructed using pairwise structural alignments to generate residue equivalences that are then ...
متن کاملUnderstanding protein structure: using scop for fold interpretation.
The structure of a protein can elucidate its function, in both general and specific terms, and its evolutionary history. Extracting this information, however, requires a knowledge of the structure and its relationships with other proteins. These two aspects are not independent, for an understanding of the structure of a single protein requires a general knowledge of the folds that proteins adop...
متن کاملSCOP database in 2004: refinements integrate structure and sequence family data
The Structural Classification of Proteins (SCOP) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationships. Protein domains in SCOP are hierarchically classified into families, superfamilies, folds and classes. The continual accumulation of sequence and structural data allows more rigorous analysis and provides importan...
متن کاملAutomated assignment of SCOP and CATH protein structure classifications from FSSP scores.
We present an automated procedure to assign CATH and SCOP classifications to proteins whose FSSP score is available. CATH classification is assigned down to the topology level, and SCOP classification is assigned to the fold level. Because the FSSP database is updated weekly, this method makes it possible to update also CATH and SCOP with the same frequency. Our predictions have a nearly perfec...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2003
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm1028